Heart & Circulation

CircO2 Review

A beetroot-and-citrulline lozenge built to raise nitric oxide for circulation.

4.4/5 Top Pick By Reviews-Supplements Editorial Team Updated August 2026

Bottom line: CircO2 is one of the more credible products in this roundup. The nitric-oxide rationale is sound, the ingredients are appropriate, and the included test strips give you a rare way to verify you're actually responding. Marketing aside, it's a well-constructed circulatory-support option backed by a strong guarantee — our top pick in the heart category.

What is CircO2?

CircO2 is a nitric-oxide (NO) support supplement from Advanced Bionutritionals, delivered as a fast-dissolving lozenge rather than a capsule. Nitric oxide is a signaling molecule that helps blood vessels relax and widen, so it's genuinely relevant to circulation, blood pressure, energy, and stamina — all of which decline with age.

What sets CircO2 apart is that it includes NO test strips so you can actually see whether your levels are responding. That measurable feedback loop is unusual and, from a trust standpoint, welcome.

How it works

The formula pairs dietary nitrate sources (beetroot) with L-citrulline, an amino acid the body converts to arginine and then to nitric oxide, plus cofactors like vitamin C and B12. Delivering it as a lozenge that dissolves in the mouth is intended to kick off nitric-oxide production via the oral route, complementing the pathway that runs through the gut.

Key ingredients

Beetroot powder
A dietary nitrate source the body can convert to nitric oxide.
L-Citrulline
An amino acid that raises arginine and supports NO synthesis and blood flow.
Hawthorn berry
A traditional cardiovascular herb used to support healthy circulation.
Vitamin C & B12
Cofactors that help protect and support nitric-oxide activity.
Magnesium
Involved in vascular tone and general cardiovascular function.

Ingredient descriptions reflect general research and traditional use. Exact per-serving amounts are set by the manufacturer; check the current label for the definitive Supplement Facts panel.

Potential benefits

  • Supports healthy nitric-oxide levels and blood flow
  • May help energy, stamina, and exercise tolerance
  • Includes test strips to verify your NO response
  • Convenient lozenge format

Pros & cons

Pros

  • Ingredients with real circulatory rationale
  • Included test strips add measurable feedback
  • Physician-formulated, transparent brand
  • 90-day 'down to the last lozenge' guarantee

Cons

  • Lozenge taste isn't for everyone
  • Results depend on diet and baseline NO status
  • Priced above basic beetroot powders
  • Marketing leans on dramatic 'superhuman' framing

Who it's for

Adults over 45 who want circulatory, energy, and stamina support, active people looking to improve exercise tolerance, and anyone who likes the idea of measuring results with the included strips. Anyone on blood-pressure or nitrate medication should check with their doctor first.

Pricing & guarantee

1 Box
$49.95
single box
Best value
3 Boxes
$44.95 / box
most popular
6 Boxes
$41.50 / box
free shipping

Guarantee: 90-day money-back guarantee. Pricing and offers are set by the seller and can change — confirm the current price on the official site before ordering.

Frequently asked questions

What does CircO2 actually do?
It supplies nitrate and L-citrulline to support your body's nitric-oxide production, which is tied to blood-vessel dilation, circulation, and stamina.
How do the test strips work?
You touch a strip to saliva and match the color to a chart to estimate your nitric-oxide level, letting you track your response over time.
How quickly might I notice something?
Nitric-oxide levels can shift within a couple of weeks, but individual responses vary with diet, age, and health status.
Is it safe with blood-pressure medication?
Because nitric oxide affects vascular tone, talk to your doctor before combining it with blood-pressure or nitrate medications.

Our verdict

CircO2 is one of the more credible products in this roundup. The nitric-oxide rationale is sound, the ingredients are appropriate, and the included test strips give you a rare way to verify you're actually responding. Marketing aside, it's a well-constructed circulatory-support option backed by a strong guarantee — our top pick in the heart category.

Ready to try CircO2?

Check current pricing, bundle discounts, and the money-back guarantee on the official website.

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This review reflects our independent editorial opinion and general research; individual results vary. Consult your healthcare provider before use. Reviews-Supplements may earn a commission if you purchase through the link above, at no additional cost to you.